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AMT-130 at Four Years: Hopeful Signs, Complex Controls
Latest News
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September 2026: This month in Huntington’s disease research
September brought progress across the HD research landscape. From brain waves and visual thinking to DNA repeats, nutrition, inclusive care, new technologies, and encouraging SKY-0515 data, we round up a busy month in Huntington’s disease research.
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Studying Stutters: What 900,000 genomes teach us about growing DNA repeats
⏱️7 min read | The CAG repeat that causes HD has a tendency to grow with age. New research on over 900,000 people uncovers parallel patterns and finds CAG growth can happen in many other parts of the genome.
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Highlighting Mental Health Disparities in Indigenous Communities Affected by Huntington’s Disease
⏱️12 min read | Unique research highlights an overlooked mental health disparity among Indigenous North American people with HD – and the need for care grounded in trust, community partnership, and cultural understanding.
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Encouraging news from Skyhawk, as SKY-0515 Phase 1/2 data continues to hold promise
Skyhawk shared data at the 15 month mark for SKY-0515 treatment in people with HD in their Phase 1/2 trial. The drug is working as designed and there are some encouraging signs that it could be helpful for some symptoms of HD.
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Food for Thought: The Importance of Nutrition in Huntington’s Disease
⏱️8 min read | What if nutrition is one of the warning lights we should be checking earlier in Huntington’s disease? New research suggests simple nutrition measures may help identify when people with HD need extra support.
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Could Brain Waves Help Track Huntington’s Disease?
⏱️7 min read | A review of 23 studies found that EEG changes were linked to disease progression and clinical measures in HD. While more research is needed, EEG holds potential to become a simple, non-invasive biomarker for monitoring HD over time.
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Hot techniques in HD research
⏱️11 min read | Five HD scientists discuss the cutting-edge techniques driving their work. These technical innovations will provide biological insights and move us closer to treatments.
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Keeping an Eye on HD: Can Visual Thinking Skills Help Track Disease Progression?
⏱️8 min read | What if Huntington’s disease changes how we “see” the world before we even notice symptoms? New research suggests visual thinking skills may help track HD progression over time.
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August 2026: This month in Huntington’s disease research
August was another busy month for HD research! Learnings from past trials, new approaches to huntingtin lowering, the start of INSIGHTT and PRECISE-HD, three packed days at HD2026, and the HDBuzz Prize: we’ve got you covered.
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First participant dosed in the PRECISE-HD trial of pridopidine
The first participant has now been dosed in the Phase 3 PRECISE-HD trial of pridopidine for HD. The study will test whether the drug can slow disease progression in people most likely to benefit
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Taking A Short Cut: New Routes to Huntingtin-Lowering Therapies
⏱️5 min read | New research points to HTT1a, a toxic shortened form of huntingtin, as a key driver of disease and a promising therapeutic target in HD.
HDBuzz Trial Tracker
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Sites for Phase 3 trial for votoplam, INVEST-HD, now open. Updates on recruitment and first dosing imminent.
REGEN4HD, Phase 1 stem cell implantation study commences
Progress update for NCT06585449 – A Study to Evaluate ALN-HTT02
